There is no native Mac version . You must run it via Parallels or Bootcamp. On Apple Silicon (M1/M2/M3), it runs okay in emulation, but the dongle drivers often fail on OS updates.
This is where E4 leaves competitors like Hatch (consumer grade) and Pulse in the dust. The render engine shows you exactly how the thread will lay . You can see light refraction on metallic threads and the "tilt" of satin stitches. This has reduced my physical test sew-offs by about 70%. wilcom e4
Here is the breakdown of what works, what doesn't, and who should buy it. E4 is the "Photoshop" of embroidery. It is overkill for a hobbyist but non-negotiable for a commercial shop. The upgrade from older versions (ES 2006/E2/E3) is significant due to speed and 3D visualization, but the subscription model is a bitter pill to swallow. There is no native Mac version